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Pregled bibliografske jedinice broj: 1006022

Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds


Duvnjak Romić, Marieta; Špoljarić, Drago; Šegvić Klarić, Maja; Cetina-Čižmek, Biserka; Filipović-Grčić, Jelena; Hafner, Anita
Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds // Journal of drug delivery science and technology, 52 (2019), 431-439 doi:10.1016/j.jddst.2019.05.004 (međunarodna recenzija, članak, znanstveni)


Naslov
Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds

Autori
Duvnjak Romić, Marieta ; Špoljarić, Drago ; Šegvić Klarić, Maja ; Cetina-Čižmek, Biserka ; Filipović-Grčić, Jelena ; Hafner, Anita

Izvornik
Journal of drug delivery science and technology (1773-2247) 52 (2019); 431-439

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Melatonin ; Nanoparticles ; Microspheres ; Chitosan ; Spray-drying ; Wound healing

Sažetak
The aim of this study was to develop nanostructured lipid carrier (NLC)-loaded chitosan-based microspheres as innovative dry powder wound dressing, with melatonin incorporated in both, NLC and chitosan matrix of the proposed hybrid system. Melatonin-loaded NLCs were prepared by a hot homogenization technique, while NLCloaded microspheres were produced by a spray-drying method. To optimize the critical formulation and process parameters for both NLC and hybrid system, a definitive screening design was employed. NLC particle size, hybrid system production yield, particle size, moisture content, and zeta potential were investigated as responses. The optimized hybrid system was characterized by prolonged melatonin release, good flowability and appropriate extent of fluid uptake. In contact with simulated wound fluid, the hybrid system swelled, turning into a hydrogel layer. The presence of lipid nanoparticles attenuated the evaporative water loss showing the potential to provide optimal hydration for moderate exuding wounds. The hybrid system was proven to be biocompatible with skin keratinocytes and fibroblasts and moreover, showed antimicrobial activity against Staphylococcus aureus and S. aureus MRSA strain.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
PLIVA HRVATSKA d.o.o.

Citiraj ovu publikaciju

Duvnjak Romić, Marieta; Špoljarić, Drago; Šegvić Klarić, Maja; Cetina-Čižmek, Biserka; Filipović-Grčić, Jelena; Hafner, Anita
Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds // Journal of drug delivery science and technology, 52 (2019), 431-439 doi:10.1016/j.jddst.2019.05.004 (međunarodna recenzija, članak, znanstveni)
Duvnjak Romić, M., Špoljarić, D., Šegvić Klarić, M., Cetina-Čižmek, B., Filipović-Grčić, J. & Hafner, A. (2019) Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds. Journal of drug delivery science and technology, 52, 431-439 doi:10.1016/j.jddst.2019.05.004.
@article{article, year = {2019}, pages = {431-439}, DOI = {10.1016/j.jddst.2019.05.004}, keywords = {Melatonin, Nanoparticles, Microspheres, Chitosan, Spray-drying, Wound healing}, journal = {Journal of drug delivery science and technology}, doi = {10.1016/j.jddst.2019.05.004}, volume = {52}, issn = {1773-2247}, title = {Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds}, keyword = {Melatonin, Nanoparticles, Microspheres, Chitosan, Spray-drying, Wound healing} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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