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Pregled bibliografske jedinice broj: 1004943

Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. A1967ctive immunization of mammary-tumor-agent-free mice


Suit, Herman D.; Silobrčić, Vlatko
Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. A1967ctive immunization of mammary-tumor-agent-free mice // Journal of the National Cancer Institute, 39 (1967), 6; 1121-1128 doi:10.1093/jnci/39.6.1121 (međunarodna recenzija, članak, znanstveni)


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Naslov
Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. A1967ctive immunization of mammary-tumor-agent-free mice
(Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. Active immunization of mammary-tumor-agent-free mice)

Autori
Suit, Herman D. ; Silobrčić, Vlatko

Izvornik
Journal of the National Cancer Institute (0027-8874) 39 (1967), 6; 1121-1128

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immunization ; active ; carcinoma ; immunologic adjuvants ; pharmaceutical adjuvants ; immunity ; animal mammary neoplasms ; mice, inbred c3h ; mice, inbred c57bl ; antibodies ; lymph nodes ; mice ; neoplasms ; spleen ; tumor cells ; tumor antigens ; breast carcinoma ; serum ; lethal dose

Sažetak
(C57BL × C3H/He)F1 mice, which do not carry a mammary tumor agent (MTA) that induces development of breast carcinoma, were actively immunized by: 1) three injections of radiation-killed tumor cells at weekly intervals, Freund' s adjuvant being included in the first injection, or 2) a tumortransplant allowed to growto ≈ 250 mm3 and then exposed to a tumor lethal dose of X radiation. In both instances, this immunity was adoptively transferred. Normal spleen and lymph node cells were not effective in immunizing against the tumor. These results contrasted with those from studies based on C3H/He and (C3H/He × C57BL)F1 mice which do carry the MTA. In these animals immunization against subsequent challenge to the mammary carcinoma was not achieved. Tests for presence of enhancing or cytotoxic antibodies in sera of (C57BL × C3H/He)F1 mice bearing a transplanted mammary carcinoma were negative.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Vlatko Silobrčić (autor)

Citiraj ovu publikaciju

Suit, Herman D.; Silobrčić, Vlatko
Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. A1967ctive immunization of mammary-tumor-agent-free mice // Journal of the National Cancer Institute, 39 (1967), 6; 1121-1128 doi:10.1093/jnci/39.6.1121 (međunarodna recenzija, članak, znanstveni)
Suit, H. & Silobrčić, V. (1967) Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. A1967ctive immunization of mammary-tumor-agent-free mice. Journal of the National Cancer Institute, 39 (6), 1121-1128 doi:10.1093/jnci/39.6.1121.
@article{article, year = {1967}, pages = {1121-1128}, DOI = {10.1093/jnci/39.6.1121}, keywords = {immunization, active, carcinoma, immunologic adjuvants, pharmaceutical adjuvants, immunity, animal mammary neoplasms, mice, inbred c3h, mice, inbred c57bl, antibodies, lymph nodes, mice, neoplasms, spleen, tumor cells, tumor antigens, breast carcinoma, serum, lethal dose}, journal = {Journal of the National Cancer Institute}, doi = {10.1093/jnci/39.6.1121}, volume = {39}, number = {6}, issn = {0027-8874}, title = {Tumor-specific antigen(s) in a spontaneous mammary carcinoma of c3h mice. II. Active immunization of mammary-tumor-agent-free mice}, keyword = {immunization, active, carcinoma, immunologic adjuvants, pharmaceutical adjuvants, immunity, animal mammary neoplasms, mice, inbred c3h, mice, inbred c57bl, antibodies, lymph nodes, mice, neoplasms, spleen, tumor cells, tumor antigens, breast carcinoma, serum, lethal dose} }

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  • MEDLINE


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