Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma (CROSBI ID 265722)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Rahman, Sadia ; Kraljević Pavelić, Sandra ; Markova-Car, Elitza
engleski
Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma
Head and neck cancer encompass different malignancies that develop in and around the throat, larynx, nose, sinuses and mouth. Most head and neck cancers are squamous cell carcinomas (HNSCC) that arise in the flat squamous cells that makeup the thin layer of tissue on the surface of anatomical structures in the head and neck. Each year, HNSCC is diagnosed in more than 600, 000 people worldwide, with about 50, 000 new cases. HNSCC is considered extremely curable if detected early. But the problem remains in treatment of inoperable cases, residues or late stages. Circadian rhythm regulation has a big role in developing various carcinomas, and head and neck tumors are no exception. A number of studies have reported that alteration in clock gene expression is associated with several cancers, including HNSCC. Analyses on circadian clock genes and their association with HNSCC have shown that expression of PER1, PER2, PER3, CRY1, CRY2, CKIε, TIM, and BMAL1 are deregulated in HNSCC tissues. This review paper comprehensively presents data on deregulation of circadian genes in HNSCC and critically evaluates their potential diagnostics and prognostics role in this type of pathology.
head and neck squamous cell carcinoma (HNSCC) ; circadian rhythm ; circadian clock genes ; cancer
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Podaci o izdanju
20 (11)
2019.
2662
16
objavljeno
1422-0067
10.3390/ijms20112662
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Temeljne medicinske znanosti