engleski

Prolonged survival of skin allografts from tumour-bearing mice

Skin grafts from Ch57BL mice bearing methylcholanthrene-induced fibrosarcoma or Ehrlich ascites carcinoma (EAC) survived longer in normal A mice than the grafts of skin from healthy C57BL mice. Fibrosarcoma showed this effect only after it had enlarged to a diameter of about 9 mm, whereas EAC was effective 3 days after inoculation. Second-set grafts of skin from EAC bearers survived longer even in mice presensitized with normal skin. On the other hand, second-set grafts of normal skin were rejected as quickly in mice grafted first with EAC-or fibrosarcoma-bearer's skin as in mice grafted first with normal skin. Serum from C57BL mice bearing EAC afforded a longer survival to skin grafts from normal C57BL and CBA mice, if injected into recipients of the grafts. Prolonged survival of the skin transplants is ascribed to "protective" substance(s) produced in mice with EAC, viz. to hypoxia and anaemia of the skin present in the mice with fibrosarcoma.

allotransplantation ; Ehrlich ascites tumor ; erythrocyte count ; fibrosarcoma ; histocompatibility ; carcinoma, ehrlich tumor ; erythrocyte count ; sarcoma, experimental ; skin Transplantation ; time factor ; transplantation immunology ; transplantation, homologou

Rad je na hrvatskom jeziku pod naslovom "Produženo preživljavanje kalema kože miševa s tumorom u alogenih primalaca" objavljen i u časopisu Libri oncologici ; 1972 (1) 1941-1945 ; ISSN 0300-8142 ; a prezentiran na skupu III Kongres kancerologa Jugoslavije ; Zagreb, Jugoslavija ; svibanj 1971.