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Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ9-Tetrahydrocannabinol


Mikolić, Anja; Žunec, Suzana; Micek, Vedran; Brčić Karačonji, Irena; Neuberg, Marijana; Kozina, Goran; Lucić Vrdoljak, Ana
Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ9-Tetrahydrocannabinol // The abstracts of The 2nd International Annual Congress on Controversies on Cannabis-Based Medicines (Med-Cannabis2019) / Häuser, Winfried ; Brill, Silviu (ur.).
Basel: S. Karger AG, Basel, 2019. str. 3-3 doi:10.1159/000500623 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ9-Tetrahydrocannabinol

Autori
Mikolić, Anja ; Žunec, Suzana ; Micek, Vedran ; Brčić Karačonji, Irena ; Neuberg, Marijana ; Kozina, Goran ; Lucić Vrdoljak, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The abstracts of The 2nd International Annual Congress on Controversies on Cannabis-Based Medicines (Med-Cannabis2019) / Häuser, Winfried ; Brill, Silviu - Basel : S. Karger AG, Basel, 2019, 3-3

Skup
The 2nd International Annual Congress on Controversies on Cannabis-Based Medicines (Med- Cannabis2019)

Mjesto i datum
Barcelona, Španjolska, 23.-23.05.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Delta-9-tetrahydrocannabinol ; oxidative stress ; cholinesterase activity ; blood ; brain ; rat

Sažetak
Background: Today, we are faced with the increasing use of illegal highly concentrated Δ9 -tetrahydrocannabinol (THC) preparations as supportive therapies for various malignancies and neurological disorders. Due to the fact that some, such as cannabis oils and butane hash oil, may contain over 80% of THC, their consumers can become intoxicated or experience various detrimental effects. Objective: The aim of this study was to assess the toxic effects of THC in male Wistar rats orally exposed to 7 mg/kg b.w. THC, which is comparable to the dose find in illicit preparations. Methods: The rats were sacrificed 24 h after treatment and plasma and brain samples were collected and stored for biochemical analyses. We determined the extent of oxidative stress as well as changes in activities of plasma and brain cholinesterases (ChE) in THC-treated and control rats. Results: Acute oral administration of 7 mg/kg b.w. THC did not cause changes in oxidative stress biomarkers in rat plasma, but did cause a significant elevation of TBARS and GSH concentration and a drop in SOD activity was observed in brain tissue. Cholinesterase activities were not affected either in the plasma or in brain tissue. Conclusion: The present study contributes to existing knowledge with evidence that acute exposure to a high THC dose induced oxidative stress in the brain, but did not affect changes in ChE activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Sveučilište Sjever, Koprivnica

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