engleski

Catestatin serum levels are inversely associated with adverse structural and hemodynamic profile among patients with acutely decompensated heart failure: preliminary echocardiographic findings

Background: Catestatin is a novel peptide with pleiotropic roles in the cardiovascular system that might have pathophysiological implications in terms of structure and function of the left ventricle (LV) among acutely decompensated heart failure (ADHF) patients. Purpose: This study tested associations of serum catestatin levels with structural and functional echocardiographic parameters of LV (Table 1). Methods: Thirty-five patients diagnosed with ADHF according to ESC 2016 HF criteria were consecutively enrolled during January-April of 2018. Each patient underwent physical and transthoracic echocardiography examination and antecubital venous blood sampling. Catestatin serum levels were determined by using an enzyme-linked immunosorbent assay (ELISA). Results: Mean age of the analyzed sample was 68 ± 10.2 years and 54.3% were men. Catestatin serum levels were in negative and significant correlation with LVEDd (r=-0.445, p=0.009), LVESd (r=-0.450, p=0.010), LVEDV (r=-0.407, p=0.021), LVESV (r=-0.407, p=0.009) and LV mass (r=-0.376, p=0.031) while they positively correlated with FS (r=0.422, p=0.016) and EF (r=0.311, p=0.039) (Figure 1). Remaining echocardiographic LV parameters did not significantly correlate with catestatin. Conclusions: Higher levels of circulating catestatinmeasured at admission of ADHF patients are significantly associated with more favorable structural remodeling and hemodynamic performance of the left ventricle.

catestatin ; acute heart failure ; pathophysiology ; echocardiography ; left ventricular ejection fraction

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