engleski

The Use of Injectable Biphasic Calcium Phosphate in a Guided Bone Regeneration: A study Plan and Preliminary Results

A guided bone regeneration (GBR) is a surgical method used to promote a bone regeneration in the situations where there is no sufficient height and width of the residual alveolar ridge to place a dental implant. An autogenous bone, allografts, xenografts, and alloplastic materials, in combination with the resorbable or nonresorbable membranes, are used in the GBR. The aim of the present study is to assess the histological and histomorphometrical changes in the alveolar bone six months subsequent to the augmentation procedure with an injectable biphasic calcium phosphate (I‐BCP). The study is designed as a prospective single‐arm one and consists of two stages. In the first stage, twenty healthy patients with an indication for GBR subsequent to a tooth extraction and prior to a dental implant placement are enrolled. The indications for a tooth extraction include a chronic periodontal disease, failure of the endodontic treatment, and a vertical fracture of the root. A patients’ selection is performed in a dental practice specialized in oral surgery, and all surgeries are performed by an experienced oral surgeon. Following the tooth extraction, the intrabony defects are filled with the I‐BCP and covered with a native collagen membrane, to ensure the isolation of a bone defect next to a soft tissue. Six months subsequent to the healing, simultaneous to a dental implant placement, bone biopsies for histological analyses are harvested and visualized under light microscopy. This report presents the preliminary histological findings of I‐BCP’s osteoconductive properties. A histological examination of the specimen revealed a new bone formation at a peripheral border of the bone defect. The I‐BCP granules of are incorporated into the bone tissue and there are no histological signs of inflammation. Therefore, we can conclude that a preliminary result of this study demonstrates an osteoconductive potential of I‐ BCP. However, further work is necessary to complete the histological, radiological, and clinical evidence of I‐BCP’s osteoconductive properties.

histomorphometry, bone biopsy, bone substitutes, dental implantology

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