engleski

Histomorphometric parameters and histological findings of the guided bone regeneration using biphasic calcium phosphate paste

Introduction: Human bone has great potential for regeneration. In ideal conditions, biomaterials in dentistry should be resorbed gradually to allow the bone defect to be fully filled with newborn bone tissue. It has been shown that rapidly resorbable biomaterials may disappear even before osteoconduction of osteogenic cells elicits and causes bone formation, while non-resorbable biomaterials prevent primary osteogenesis as well as maturation of bone tissue. Aim: Guided Bone Regeneration (GBR), which is one of the most frequently, used techniques in implant dentistry, with a predictable clinical outcome. In present study, we want to assess and describe histological indices of the bone sample, 6 months after GBR. We also wanted to quantify the percentage of the newly formed bone, percentage of the residual biomaterial and percentage of the soft tissue. Materials and methods: Ten healthy patients were included in the study with at least one or two wall intrabony defects after tooth extraction. The intrabony defects were filled with biphasic calcium phosphate paste (Maxresorb inject, Botiss Dental GmbH) and covered with native collagen membrane (Jason membrane, Botiss Dental GmbH), to ensure the isolation of the bone defect against gingival connective tissue. Six months after healing, simultaneously with dental implant placement, bone biopsies were collected and values of the histomorphometric parameters were determined. Results: Histological indices showed new bone formation at the peripheral border of the bone defect. The granules of Maxresorb inject are incorporated into bone tissue and there with no histological signs of inflammation. Histomorphometry reveals 18% of the newly formed bone, 30% of the residual biomaterial and 40% of the soft tissue. Conclusions: In present study, we evaluated the regenerated bone by descriptive histological examination and histomorphometry. Maxresorb inject shows octeoconductive potential for bone regeneration.

Guided bone regeneration, implant dentistry, Maxresorb inject, histology, histomorphometry

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