Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Helical Twist and Rotational Forces in the Mitotic Spindle (CROSBI ID 265428)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Tolić, Iva M. ; Novak, Maja ; Pavin, Nenad Helical Twist and Rotational Forces in the Mitotic Spindle // Biomolecules, 9 (2019), 4; 132, 10. doi: 10.3390/biom9040132

Podaci o odgovornosti

Tolić, Iva M. ; Novak, Maja ; Pavin, Nenad

engleski

Helical Twist and Rotational Forces in the Mitotic Spindle

The mitotic spindle segregates chromosomes into two daughter cells during cell division. This process relies on the precise regulation of forces acting on chromosomes as the cell progresses through mitosis. The forces in the spindle are difficult to directly measure using the available experimental techniques. Here, we review the ideas and recent advances of how forces can be determined from the spindle shape. By using these approaches, it has been shown that tension and compression coexist along a single kinetochore fiber, which are balanced by a bridging fiber between sister kinetochore fibers. An extension of this approach to three dimensions revealed that microtubule bundles have rich shapes, and extend not simply like meridians on the Earth’s surface but, rather, twisted in a helical manner. Such complex shapes are due to rotational forces, which, in addition to linear forces, act in the spindle and may be generated by motor proteins such as kinesin-5. These findings open new questions for future studies, to understand the mechanisms of rotational forces and reveal their biological roles in cells.

mitotic spindle ; forces ; microtubules ; motor proteins ; rotational forces ; torque

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

9 (4)

2019.

132

10

objavljeno

2218-273X

10.3390/biom9040132

Povezanost rada

Biologija, Fizika

Poveznice
Indeksiranost