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Pregled bibliografske jedinice broj: 1003586

Helical Twist and Rotational Forces in the Mitotic Spindle


Tolić, Iva M.; Novak, Maja; Pavin, Nenad
Helical Twist and Rotational Forces in the Mitotic Spindle // Biomolecules, 9 (2019), 4; 132, 10 doi:10.3390/biom9040132 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Helical Twist and Rotational Forces in the Mitotic Spindle

Autori
Tolić, Iva M. ; Novak, Maja ; Pavin, Nenad

Izvornik
Biomolecules (2218-273X) 9 (2019), 4; 132, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
mitotic spindle ; forces ; microtubules ; motor proteins ; rotational forces ; torque

Sažetak
The mitotic spindle segregates chromosomes into two daughter cells during cell division. This process relies on the precise regulation of forces acting on chromosomes as the cell progresses through mitosis. The forces in the spindle are difficult to directly measure using the available experimental techniques. Here, we review the ideas and recent advances of how forces can be determined from the spindle shape. By using these approaches, it has been shown that tension and compression coexist along a single kinetochore fiber, which are balanced by a bridging fiber between sister kinetochore fibers. An extension of this approach to three dimensions revealed that microtubule bundles have rich shapes, and extend not simply like meridians on the Earth’s surface but, rather, twisted in a helical manner. Such complex shapes are due to rotational forces, which, in addition to linear forces, act in the spindle and may be generated by motor proteins such as kinesin-5. These findings open new questions for future studies, to understand the mechanisms of rotational forces and reveal their biological roles in cells.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija



POVEZANOST RADA


Projekti:
IP-2014-09-4753 - Oscilatorna dinamika citoskeleta (OSCITON) (Tolić, Iva Marija, HRZZ - 2014-09) ( POIROT)
EK-H2020-647077 - A new class of microtubules in the spindle exerting forces on kinetochores (NewSpindleForce) (Tolić, Iva Marija, EK - ERC-2014-CoG) ( POIROT)
EK-EFRR-KK.01.1.1.01.0004 - Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri (QuantiXLie) (Buljan, Hrvoje; Pandžić, Pavle, EK - Vrhunska istraživanja Znanstvenih centara izvrsnosti - KK.01.1.1.01) ( POIROT)
Ostalo-18/15 - The role of microtubule pivoting in formation of complex structures such as microtubule bundles and mitotic spindles (Pavin, Nenad, Ostalo ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Maja Novak (autor)

Avatar Url Nenad Pavin (autor)

Avatar Url Iva Marija Tolić (autor)

Citiraj ovu publikaciju

Tolić, Iva M.; Novak, Maja; Pavin, Nenad
Helical Twist and Rotational Forces in the Mitotic Spindle // Biomolecules, 9 (2019), 4; 132, 10 doi:10.3390/biom9040132 (međunarodna recenzija, pregledni rad, znanstveni)
Tolić, I., Novak, M. & Pavin, N. (2019) Helical Twist and Rotational Forces in the Mitotic Spindle. Biomolecules, 9 (4), 132, 10 doi:10.3390/biom9040132.
@article{article, year = {2019}, pages = {10}, DOI = {10.3390/biom9040132}, chapter = {132}, keywords = {mitotic spindle, forces, microtubules, motor proteins, rotational forces, torque}, journal = {Biomolecules}, doi = {10.3390/biom9040132}, volume = {9}, number = {4}, issn = {2218-273X}, title = {Helical Twist and Rotational Forces in the Mitotic Spindle}, keyword = {mitotic spindle, forces, microtubules, motor proteins, rotational forces, torque}, chapternumber = {132} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE


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