Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin (CROSBI ID 265403)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kapić, Samra ; Fajdetić, Andrea ; Koštrun, Sanja ; Čikoš, Ana ; Paljetak, Hana Čipčić ; Antolović, Roberto ; Holmes, David J. ; Alihodžić, Sulejman
engleski
Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin
A set of novel macrolones containing the flexible C8 basic linker and quinolone 3-(2′-hydroxyethyl)carboxamido group has been prepared and structurally characterized by NMR and IR spectroscopy, mass spectrometry and molecular modeling. The new compounds were evaluated in vitro against a panel of erythromycin-susceptible and erythromycin-resistant Gram-positive and Gram-negative bacterial strains. Compared to azithromycin, most of the compounds exhibited improved in vitro potency against the key respiratory pathogens.
Antimicrobial activity ; Macrolides ; Macrolones ; Quinolone ; Structure–activity relationship
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Podaci o izdanju
19 (23)
2011.
7270-7280
objavljeno
0968-0896
10.1016/j.bmc.2011.07.011