engleski

Molecular and genetic basis of the intestinal adherence for porcine enterotoxigenic Escherichia coli strains

Although Escherichia coli is a normal inhabitant of the intestinal tract of animals and humans, this organism can also cause disease. Most of these diseases are each associated with relatively few host-specific serological groups of E.coli, even though a very large number exist in nature. In swine, E.coli exerts its most serious effect on young pigs, causing a number of disease syndromes of which only neonatal and postweaning diarrhea or colibacillosis caused by enterotoxigenic strains will be discussed. Porcine enetrotoxigenic E.coli (ETEC) are divided according to their serogroup, the type of adhesins/enterotoxins they produce, and their in vivo enteropathogenicity. However, we have restricted our discussion to selected topics on the structure, function, and morphology of known proteinaceus adhesive materials of porcine ETEC, the receptors with wich they interact, and the genetical implications of their interactions resulting in attachment. There are two approaches to the prevention of ETEC infections. The first one attempts to minimize factors that predispose to enteric colibacillosis, and the second is more specifically directed at the causative agent. Age and genetic background seem to determine the inherent susceptibility of pigs to ETEC. Accordingly, we will focus on molecular and genetc basis of intestinal adherence for ETEC and the role of their adhesins and toxins in colonization of pig small intestine and induction of diarrheal disease.

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