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Pregled bibliografske jedinice broj: 1002558

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans


Russell, Alyce C.; Kepka, Agnieszka; Trbojević-Akmačić, Irena; Ugrina, Ivo; Song, Manshu; Hui, Jennie; Hunter, Michael; Laws, Simon M.; Lauc, Gordan; Wang, Wei
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans // Immunobiology, 224 (2019), 1; 110-115 doi:10.1016/j.imbio.2018.10.002 (međunarodna recenzija, članak, znanstveni)


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Naslov
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Autori
Russell, Alyce C. ; Kepka, Agnieszka ; Trbojević-Akmačić, Irena ; Ugrina, Ivo ; Song, Manshu ; Hui, Jennie ; Hunter, Michael ; Laws, Simon M. ; Lauc, Gordan ; Wang, Wei

Izvornik
Immunobiology (0171-2985) 224 (2019), 1; 110-115

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Body mass index ; Central adiposity ; Glycosylation ; Immunoglobulin G ; Pro-inflammation

Sažetak
Background Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans. Aim We aimed to determine the association between increased body fat and the immunoglobulin G glycosylation features, comparing body mass index to other measures of body fat distribution. Methods We investigated a sample of 637 community-based 45–69 year olds, with mixed phenotypes, residing in Busselton, Western Australia. Body mass index and the waist-to-hip and waist-to-height ratios were calculated using anthropometry, while dual-energy x-ray absorptiometry was performed to gain an accurate measure of total and area specific body fat. Serum immunoglobulin GN-glycans were analysed by ultra-performance liquid chromatography. Results Twenty-two N-glycan peaks were found to be associated with at least one of the fat measures. While the previous association of body mass index to agalactosylated immunoglobulin G was replicated, measures of central adiposity explained the most variation in the immunoglobulin G glycome. Conclusion Central adiposity is associated with an increased pro-inflammatory fraction of immunoglobulin G, suggesting that the android/gynoid ratio or waist-to-height ratio instead be considered when controlling for adiposity in immunoglobulin G glycome biomarker studies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
EK-FP7-305280 (EK - FP7-HEALTH-2012-INNOVATION-1)
EK-FP7-324400 (EK - FP7-PEOPLE-2012-IAPP)
EK-FP7-602736 (EK - FP7-HEALTH-2013-INNOVATION-1)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Sveučilište u Splitu,
GENOS d.o.o.

Profili:

Avatar Url Gordan Lauc (autor)

Avatar Url Ivo Ugrina (autor)

Avatar Url Irena Trbojević Akmačić (autor)

Citiraj ovu publikaciju

Russell, Alyce C.; Kepka, Agnieszka; Trbojević-Akmačić, Irena; Ugrina, Ivo; Song, Manshu; Hui, Jennie; Hunter, Michael; Laws, Simon M.; Lauc, Gordan; Wang, Wei
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans // Immunobiology, 224 (2019), 1; 110-115 doi:10.1016/j.imbio.2018.10.002 (međunarodna recenzija, članak, znanstveni)
Russell, A., Kepka, A., Trbojević-Akmačić, I., Ugrina, I., Song, M., Hui, J., Hunter, M., Laws, S., Lauc, G. & Wang, W. (2019) Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans. Immunobiology, 224 (1), 110-115 doi:10.1016/j.imbio.2018.10.002.
@article{article, year = {2019}, pages = {110-115}, DOI = {10.1016/j.imbio.2018.10.002}, keywords = {Body mass index, Central adiposity, Glycosylation, Immunoglobulin G, Pro-inflammation}, journal = {Immunobiology}, doi = {10.1016/j.imbio.2018.10.002}, volume = {224}, number = {1}, issn = {0171-2985}, title = {Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans}, keyword = {Body mass index, Central adiposity, Glycosylation, Immunoglobulin G, Pro-inflammation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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