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Pregled bibliografske jedinice broj: 1002548

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases


Šimurina, Mirna; de Haan, Noortje; Vučković, Frano; Kennedy, Nicholas A.; Štambuk, Jerko; Falck, David; Trbojević-Akmačić, Irena; Clerc, Florent; Razdorov, Genadij; Khon, Anna et al.
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases // Gastroenterology (New York, N.Y. 1943), 154 (2018), 5; 1320-1333e10 doi:10.1053/j.gastro.2018.01.002 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1002548 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

Autori
Šimurina, Mirna ; de Haan, Noortje ; Vučković, Frano ; Kennedy, Nicholas A. ; Štambuk, Jerko ; Falck, David ; Trbojević-Akmačić, Irena ; Clerc, Florent ; Razdorov, Genadij ; Khon, Anna ; Latiano, Anna ; D'Incà, Renata ; Danese, Silvio ; Targan, Stephan ; Landers, Carol ; Dubinsky, Marla ; McGovern, Dermot P.B. ; Annese, Vito ; Wuhrer, Manfred ; Lauc, Gordan ; Campbell, Harry ; Zoldoš, Vlatka ; Permberton, Iain K. ; Kolarich, Daniel ; Fernandes, Daryl L. ; Theorodorou, Evropi ; Merrick, Victoria ; Spencer, Daniel I. ; Gardner, Richard A. ; Doran, Ray ; Shubhakar, Archana ; Boyapati, Ray ; Rudan, Igor ; Lionetti, Paolo ; Krištić, Jasminka ; Novokmet, Mislav ; Pučić-Baković, Maja ; Gornik, Olga ; Andriulli, Angelo ; Cantoro, Laura ; Sturniolo, Giancarlo ; Fiorino, Gionata ; Manetti, Natalia ; Arnott, Ian D. ; Noble, Colin L. ; Lees, Charlie W. ; Shand, Alan G. ; Ho, Gwo-Tzer ; Dunlop, Malcolm G. ; Murphy, Lee ; Gibson, Jude ; Evenden, Louise ; Wrobel, Nicola ; Gilchrist, Tamara ; Fawkes, Angie ; Kammeijer, Guinevere S.M. ; Vojta, Aleksandar ; Samaržija, Ivana ; Markulin, Dora ; Klasić, Marija ; Dobrinić, Paula ; Aulchenko, Yurii ; van den Heuve, Tim ; Jonkers, Daisy ; Pierik, Marieke

Izvornik
Gastroenterology (New York, N.Y. 1943) (0016-5085) 154 (2018), 5; 1320-1333e10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IBD ; glycans ; glycopeptides ; biomarker

Sažetak
BACKGROUND AND AIMS: Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn's disease (CD) and ulcerative colitis (UC), are sometimes hard to distinguish. Glycosylation of IgG has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc- glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups. METHODS: We analyzed 3441 plasma samples obtained from 2 independent cohorts of patients with CD (874 patients from Italy and 391 from the United States) or UC (1056 from Italy and 253 from the US and healthy individuals [controls] ; 427 in Italy and 440 from the United States). IgG Fc-glycosylation (tryptic glycopeptides) was analyzed by liquid chromatography coupled to mass spectrometry. We analyzed associations between disease status (UC vs controls, CD vs controls, and UC vs CD) and glycopeptide traits, and associations between clinical characteristics and glycopeptide traits, using a logistic regression model with age and sex included as covariates. RESULTS: Patients with CD or UC had lower levels of IgG galactosylation than controls. For example, the odds ratio (OR) for IgG1 galactosylation in patients with CD was 0.59 (95% confidence interval [CI], 0.51-0.69) and for patients with UC was 0.81 (95% CI, 0.71-0.92). Fucosylation of IgG was increased in patients with CD vs controls (for IgG1: OR, 1.27 ; 95% CI, 1.12-1.44), but decreased in patients with UC vs controls (for IgG23: OR, 0.72 ; 95% CI, 0.63-0.82). Decreased galactosylation associated with more severe CD or UC, including the need for surgery in patients with UC vs controls (for IgG1: OR, 0.69 ; 95% CI, 0.54-0.89) and in patients with CD vs controls (for IgG23: OR, 0.78 ; 95% CI, 0.66-0.91). CONCLUSIONS: In a retrospective analysis of plasma samples from patients with CD or UC, we associated levels of IgG Fc-glycosylation with disease (compared to controls) and its clinical features. These findings could increase our understanding of mechanisms of CD and UC pathogenesis and be used to develop diagnostics or guide treatment.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
EK-FP7-305479 - Diagnostic and prognostic biomarkers for inflammatory bowel disease (IBD-BIOM) (Zoldoš, Vlatka, EK - FP7-HEALTH-2012-INNOVATION-1) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
GENOS d.o.o.

Poveznice na cjeloviti tekst rada:

doi www.gastrojournal.org

Citiraj ovu publikaciju:

Šimurina, Mirna; de Haan, Noortje; Vučković, Frano; Kennedy, Nicholas A.; Štambuk, Jerko; Falck, David; Trbojević-Akmačić, Irena; Clerc, Florent; Razdorov, Genadij; Khon, Anna et al.
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases // Gastroenterology (New York, N.Y. 1943), 154 (2018), 5; 1320-1333e10 doi:10.1053/j.gastro.2018.01.002 (međunarodna recenzija, članak, znanstveni)
Šimurina, M., de Haan, N., Vučković, F., Kennedy, N., Štambuk, J., Falck, D., Trbojević-Akmačić, I., Clerc, F., Razdorov, G. & Khon, A. (2018) Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases. Gastroenterology (New York, N.Y. 1943), 154 (5), 1320-1333e10 doi:10.1053/j.gastro.2018.01.002.
@article{article, author = {\v{S}imurina, Mirna and de Haan, Noortje and Vu\v{c}kovi\'{c}, Frano and Kennedy, Nicholas A. and \v{S}tambuk, Jerko and Falck, David and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Clerc, Florent and Razdorov, Genadij and Khon, Anna and Latiano, Anna and D'Inc\`{a}, Renata and Danese, Silvio and Targan, Stephan and Landers, Carol and Dubinsky, Marla and McGovern, Dermot P.B. and Annese, Vito and Wuhrer, Manfred and Lauc, Gordan and Campbell, Harry and Zoldo\v{s}, Vlatka and Permberton, Iain K. and Kolarich, Daniel and Fernandes, Daryl L. and Theorodorou, Evropi and Merrick, Victoria and Spencer, Daniel I. and Gardner, Richard A. and Doran, Ray and Shubhakar, Archana and Boyapati, Ray and Rudan, Igor and Lionetti, Paolo and Kri\v{s}ti\'{c}, Jasminka and Novokmet, Mislav and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Gornik, Olga and Andriulli, Angelo and Cantoro, Laura and Sturniolo, Giancarlo and Fiorino, Gionata and Manetti, Natalia and Arnott, Ian D. and Noble, Colin L. and Lees, Charlie W. and Shand, Alan G. and Ho, Gwo-Tzer and Dunlop, Malcolm G. and Murphy, Lee and Gibson, Jude and Evenden, Louise and Wrobel, Nicola and Gilchrist, Tamara and Fawkes, Angie and Kammeijer, Guinevere S.M. and Vojta, Aleksandar and Samar\v{z}ija, Ivana and Markulin, Dora and Klasi\'{c}, Marija and Dobrini\'{c}, Paula and Aulchenko, Yurii and van den Heuve, Tim and Jonkers, Daisy and Pierik, Marieke}, year = {2018}, pages = {1320-1333e10}, DOI = {10.1053/j.gastro.2018.01.002}, keywords = {IBD, glycans, glycopeptides, biomarker}, journal = {Gastroenterology (New York, N.Y. 1943)}, doi = {10.1053/j.gastro.2018.01.002}, volume = {154}, number = {5}, issn = {0016-5085}, title = {Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases}, keyword = {IBD, glycans, glycopeptides, biomarker} }
@article{article, author = {\v{S}imurina, Mirna and de Haan, Noortje and Vu\v{c}kovi\'{c}, Frano and Kennedy, Nicholas A. and \v{S}tambuk, Jerko and Falck, David and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Clerc, Florent and Razdorov, Genadij and Khon, Anna and Latiano, Anna and D'Inc\`{a}, Renata and Danese, Silvio and Targan, Stephan and Landers, Carol and Dubinsky, Marla and McGovern, Dermot P.B. and Annese, Vito and Wuhrer, Manfred and Lauc, Gordan and Campbell, Harry and Zoldo\v{s}, Vlatka and Permberton, Iain K. and Kolarich, Daniel and Fernandes, Daryl L. and Theorodorou, Evropi and Merrick, Victoria and Spencer, Daniel I. and Gardner, Richard A. and Doran, Ray and Shubhakar, Archana and Boyapati, Ray and Rudan, Igor and Lionetti, Paolo and Kri\v{s}ti\'{c}, Jasminka and Novokmet, Mislav and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Gornik, Olga and Andriulli, Angelo and Cantoro, Laura and Sturniolo, Giancarlo and Fiorino, Gionata and Manetti, Natalia and Arnott, Ian D. and Noble, Colin L. and Lees, Charlie W. and Shand, Alan G. and Ho, Gwo-Tzer and Dunlop, Malcolm G. and Murphy, Lee and Gibson, Jude and Evenden, Louise and Wrobel, Nicola and Gilchrist, Tamara and Fawkes, Angie and Kammeijer, Guinevere S.M. and Vojta, Aleksandar and Samar\v{z}ija, Ivana and Markulin, Dora and Klasi\'{c}, Marija and Dobrini\'{c}, Paula and Aulchenko, Yurii and van den Heuve, Tim and Jonkers, Daisy and Pierik, Marieke}, year = {2018}, pages = {1320-1333e10}, DOI = {10.1053/j.gastro.2018.01.002}, keywords = {IBD, glycans, glycopeptides, biomarker}, journal = {Gastroenterology (New York, N.Y. 1943)}, doi = {10.1053/j.gastro.2018.01.002}, volume = {154}, number = {5}, issn = {0016-5085}, title = {Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases}, keyword = {IBD, glycans, glycopeptides, biomarker} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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