Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1002545

N-Glycan Profile and Kidney Disease in Type 1 Diabetes


Bermingham, Mairead L.; Colombo, Marco; McGurnaghan, Stuart J.; Blackbourn, Luke A.K.; Vučković, Frano; Pučić Baković, Maja; Trbojević-Akmačić, Irena; Lauc, Gordan; Agakov, Felix; Agakova, Anna S. et al.
N-Glycan Profile and Kidney Disease in Type 1 Diabetes // Diabetes Care, 41 (2017), 1; 79-87 doi:10.2337/dc17-1042 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1002545 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
N-Glycan Profile and Kidney Disease in Type 1 Diabetes

Autori
Bermingham, Mairead L. ; Colombo, Marco ; McGurnaghan, Stuart J. ; Blackbourn, Luke A.K. ; Vučković, Frano ; Pučić Baković, Maja ; Trbojević-Akmačić, Irena ; Lauc, Gordan ; Agakov, Felix ; Agakova, Anna S. ; Hayward, Caroline ; Klarić, Lucija ; Palmer, Colin N.A. ; Petrie, John R. ; Chalmers, John ; Collier, Andrew ; Green, Fiona ; Lindsay, Robert S. ; Macrury, Sandra ; McKnight, John A. ; Patrick, Alan W. ; Thekkepat, Sandeep ; Gornik, Olga ; McKeigue, Paul M. ; Colhoun, Helen M.

Izvornik
Diabetes Care (0149-5992) 41 (2017), 1; 79-87

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Type 1 Diabetes

Sažetak
OBJECTIVE Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND METHODS Using serum samples from 818 adults who were considered to have extreme annual loss in estimated glomerular filtration rate (eGFR ; i.e., slope) based on retrospective clinical records, from among 6, 127 adults in the Scottish Diabetes Research Network Type 1 Bioresource Study, we measured total and IgG-specific N-glycan profiles. This yielded a relative abundance of 39 total (GP) and 24 IgG (IGP) N-glycans. Linear regression models were used to investigate associations between N-glycan structures and HbA1c, albumin-to-creatinine ratio (ACR), and eGFR slope. Models were adjusted for age, sex, duration of type 1 diabetes, and total serum IgG. RESULTS Higher HbA1c was associated with a lower relative abundance of simple biantennary N-glycans and a higher relative abundance of more complex structures with more branching, galactosylation, and sialylation (GP12, 26, 31, 32, and 34, and IGP19 and 23 ; all P < 3.79 × 10−4). Similar patterns were seen for ACR and greater mean annual loss of eGFR, which were also associated with fewer of the simpler N-glycans (all P < 3.79 × 10−4). CONCLUSIONS Higher HbA1c in type 1 diabetes is associated with changes in the serum N-glycome that have elsewhere been shown to regulate the epidermal growth factor receptor and transforming growth factor-β pathways that are implicated in DKD. Furthermore, N-glycans are associated with ACR and eGFR slope. These data suggest that the role of altered N-glycans in DKD warrants further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-UIP-2014-09-7769 - Glikozilacija plazmatskih proteina u razumijevanju dijabetesa tipa 1 (GLYCO-T1D) (Gornik, Olga, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Citiraj ovu publikaciju:

Bermingham, Mairead L.; Colombo, Marco; McGurnaghan, Stuart J.; Blackbourn, Luke A.K.; Vučković, Frano; Pučić Baković, Maja; Trbojević-Akmačić, Irena; Lauc, Gordan; Agakov, Felix; Agakova, Anna S. et al.
N-Glycan Profile and Kidney Disease in Type 1 Diabetes // Diabetes Care, 41 (2017), 1; 79-87 doi:10.2337/dc17-1042 (međunarodna recenzija, članak, znanstveni)
Bermingham, M., Colombo, M., McGurnaghan, S., Blackbourn, L., Vučković, F., Pučić Baković, M., Trbojević-Akmačić, I., Lauc, G., Agakov, F. & Agakova, A. (2017) N-Glycan Profile and Kidney Disease in Type 1 Diabetes. Diabetes Care, 41 (1), 79-87 doi:10.2337/dc17-1042.
@article{article, author = {Bermingham, Mairead L. and Colombo, Marco and McGurnaghan, Stuart J. and Blackbourn, Luke A.K. and Vu\v{c}kovi\'{c}, Frano and Pu\v{c}i\'{c} Bakovi\'{c}, Maja and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Lauc, Gordan and Agakov, Felix and Agakova, Anna S. and Hayward, Caroline and Klari\'{c}, Lucija and Palmer, Colin N.A. and Petrie, John R. and Chalmers, John and Collier, Andrew and Green, Fiona and Lindsay, Robert S. and Macrury, Sandra and McKnight, John A. and Patrick, Alan W. and Thekkepat, Sandeep and Gornik, Olga and McKeigue, Paul M. and Colhoun, Helen M.}, year = {2017}, pages = {79-87}, DOI = {10.2337/dc17-1042}, keywords = {Type 1 Diabetes}, journal = {Diabetes Care}, doi = {10.2337/dc17-1042}, volume = {41}, number = {1}, issn = {0149-5992}, title = {N-Glycan Profile and Kidney Disease in Type 1 Diabetes}, keyword = {Type 1 Diabetes} }
@article{article, author = {Bermingham, Mairead L. and Colombo, Marco and McGurnaghan, Stuart J. and Blackbourn, Luke A.K. and Vu\v{c}kovi\'{c}, Frano and Pu\v{c}i\'{c} Bakovi\'{c}, Maja and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Lauc, Gordan and Agakov, Felix and Agakova, Anna S. and Hayward, Caroline and Klari\'{c}, Lucija and Palmer, Colin N.A. and Petrie, John R. and Chalmers, John and Collier, Andrew and Green, Fiona and Lindsay, Robert S. and Macrury, Sandra and McKnight, John A. and Patrick, Alan W. and Thekkepat, Sandeep and Gornik, Olga and McKeigue, Paul M. and Colhoun, Helen M.}, year = {2017}, pages = {79-87}, DOI = {10.2337/dc17-1042}, keywords = {Type 1 Diabetes}, journal = {Diabetes Care}, doi = {10.2337/dc17-1042}, volume = {41}, number = {1}, issn = {0149-5992}, title = {N-Glycan Profile and Kidney Disease in Type 1 Diabetes}, keyword = {Type 1 Diabetes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font