engleski

Association of poor periodontal health in younger schizophrenia patients with a worsening of symptoms during remission: a prospective cohort study

Objectives The aim of this prospective cohort study was to investigate whether the association of periodontal status with schizophrenia treatment outcomes differs by patient’s age. Subjects and methods The study was performed on the consecutive sample of 67 patients diagnosed with schizophrenia and discharged because achieving remission criteria. Papilla bleeding index (PBI) was measured at hospital discharge. Positive and negative syndrome scale (PANSS) total score, positive, negative and general symptoms subscales’ scores were measured at hospital discharge, after three, and after six months. Results After the adjustment for potential confounders, baseline PBI was significantly unfavorably associated with PANSS total score, negative and general symptoms subscales scores in the patients younger than 45 three and six months after the hospital discharge, and with the positive symptoms sub-scale in patients younger than 34. At youngest 10% of patients, a unit difference in baseline PBI resulted in the 8.12 (95% CI 2.78-13.47 ; p=0.004) points higher total PANSS score three months later. Conclusions Our study showed that the younger patients with worse periodontal status are at higher risk for poorer schizophrenia treatment outcomes and faster worsening of remission. This study demonstrates the necessity of more rigorous and more frequent control of younger schizophrenia patients with worse periodontal status after hospital discharge to achieve overall improvement of the patients’ quality of life as well as the efficacy of psychiatric therapies aimed toward the primary mental disorder.

papilla bleeding ; PANSS ; schizophrenia ; periodontal status

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