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Dissolution characteristics of nifedipine complexes with beta-cyclodextrins


Bećirević-Laćan, Mira; Filipović-Grčić, Jelena; Škalko, Nataša; Jalšenjak, Ivan
Dissolution characteristics of nifedipine complexes with beta-cyclodextrins // Drug development and industrial pharmacy, 22 (1996), 12; 1231-1236 (međunarodna recenzija, članak, znanstveni)


Naslov
Dissolution characteristics of nifedipine complexes with beta-cyclodextrins

Autori
Bećirević-Laćan, Mira ; Filipović-Grčić, Jelena ; Škalko, Nataša ; Jalšenjak, Ivan

Izvornik
Drug development and industrial pharmacy (0363-9045) 22 (1996), 12; 1231-1236

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chitosa; nifedipine; cyclodextrin complexes; microspheres; sustained release

Sažetak
Formation of nifedipine complexes with beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin, and DIMEB in solution was studied by the phase solubility method. Solid complexes of nifedipine were prepared by partial and complete solubilization of nifedipine using the freeze- and spray-drying techniques. The complexation led to an improvement in the dissolution rate of the drug. The relative potency of beta-cyclodextrins to enhance the dissolution rate of nifedipine was in order: beta-cyclodextrin < hydroxypropyl-beta-cyclodextrin < DIMEB, which clearly fits the magnitude of stability constant data of the complexes. The dissolution rates of the free drug, complexes, and physical mixture of drug and cyclodextrins from constant surface area disks were also investigated.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
006250

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju

Bećirević-Laćan, Mira; Filipović-Grčić, Jelena; Škalko, Nataša; Jalšenjak, Ivan
Dissolution characteristics of nifedipine complexes with beta-cyclodextrins // Drug development and industrial pharmacy, 22 (1996), 12; 1231-1236 (međunarodna recenzija, članak, znanstveni)
Bećirević-Laćan, M., Filipović-Grčić, J., Škalko, N. & Jalšenjak, I. (1996) Dissolution characteristics of nifedipine complexes with beta-cyclodextrins. Drug development and industrial pharmacy, 22 (12), 1231-1236.
@article{article, year = {1996}, pages = {1231-1236}, keywords = {chitosa, nifedipine, cyclodextrin complexes, microspheres, sustained release}, journal = {Drug development and industrial pharmacy}, volume = {22}, number = {12}, issn = {0363-9045}, title = {Dissolution characteristics of nifedipine complexes with beta-cyclodextrins}, keyword = {chitosa, nifedipine, cyclodextrin complexes, microspheres, sustained release} }

Časopis indeksira:


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