Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1001812

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways


Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways // Food and chemical toxicology, 132 (2019), 110676, 10 doi:10.1016/j.fct.2019.110676 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1001812 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways

Autori
Potočnjak, Iva ; Šimić, Lidija ; Vukelić, Iva ; Domitrović, Robert

Izvornik
Food and chemical toxicology (0278-6915) 132 (2019); 110676, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oleanolic acid ; cisplatin ; oxidative stress ; inflammation ; apoptosis ; autophagy

Sažetak
Oleanolic acid (OA) is a natural triterpenoid that possesses numerous beneficial health effects such as antioxidant, anti-inflammatory and anti-apoptotic activities. In this study, we investigated the therapeutic effect of OA (10 and 40 mg/kg) on cisplatin (CP)-induced (13 mg/kg) nephrotoxicity. Treatment with OA 40 mg/kg once daily for 2 days, 48 h after CP- intoxication, ameliorated the increased serum markers and histological features of kidney injury. CP administration increased renal expression of antioxidant and anti-inflammatory markers, which was reduced by OA. The increase in proapoptotic caspase-3 and -9 activations, with concomitant increase in poly (ADP-ribose) polymerase (PARP) cleavage, were dose- dependently inhibited by OA. Treatment with OA also ameliorated microtubule-associated protein 1A/1B-light chain 3B (LC3B)-II and autophagy- related protein (Atg) 5 expression induced by CP. The suppression of CP-induced oxidative stress, apoptosis, autophagy and inflammatory response by OA coincided with the inhibition of extracellular-regulated kinase (ERK) 1/2, signal transducer and activator of transcription (STAT) 3 and nuclear factor-kappa B (NF-κB). Interestingly, OA increased CP cytotoxicity in HeLa cervical cancer cells by inducing cytotoxic autophagy. The chemosensitization of HeLa cells to CP suggests a potential beneficial effect of OA in cervical cancer patients due to reduced CP dosage requirements, which requires further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
uniri-biomed-18-30

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Iva Potočnjak (autor)

Avatar Url Iva Vukelić (autor)

Avatar Url Robert Domitrović (autor)

Citiraj ovu publikaciju

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways // Food and chemical toxicology, 132 (2019), 110676, 10 doi:10.1016/j.fct.2019.110676 (međunarodna recenzija, članak, znanstveni)
Potočnjak, I., Šimić, L., Vukelić, I. & Domitrović, R. (2019) Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways. Food and chemical toxicology, 132, 110676, 10 doi:10.1016/j.fct.2019.110676.
@article{article, year = {2019}, pages = {10}, DOI = {10.1016/j.fct.2019.110676}, chapter = {110676}, keywords = {oleanolic acid, cisplatin, oxidative stress, inflammation, apoptosis, autophagy}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2019.110676}, volume = {132}, issn = {0278-6915}, title = {Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways}, keyword = {oleanolic acid, cisplatin, oxidative stress, inflammation, apoptosis, autophagy}, chapternumber = {110676} }
@article{article, year = {2019}, pages = {10}, DOI = {10.1016/j.fct.2019.110676}, chapter = {110676}, keywords = {oleanolic acid, cisplatin, oxidative stress, inflammation, apoptosis, autophagy}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2019.110676}, volume = {132}, issn = {0278-6915}, title = {Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signaling pathways}, keyword = {oleanolic acid, cisplatin, oxidative stress, inflammation, apoptosis, autophagy}, chapternumber = {110676} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font