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Synthesis and characterization of copper(II) complexes with glycine and heterocyclic bases

Copper complexes with aminoacids as ligands are often used as model systems for investigation of copper containing proteins. Copper(II) complexes with 1, 10-phenanthroline and L- Val/L-Arg/L-Leu/L-Met possess superoxide dismutase-like activities 1, 2. Moreover, copper(II) complexes with 1, 10-phenanthroline possess various biological activities such as antibacterial, antifungal and antiproliferative effects on tumor cells, DNA binding and have potential application in biomedicine 3-5. In this work we report synthesis and solid-state characterization (X-ray structural analysis, IR spectroscopy and TG/DTA analysis) of new complexes of copper(II) with glycine and a heterocyclic base (1, 10-phenanthroline (phen) and 2, 2′-bipyridine (bpy)), Cu(gly)(H2O) (phen)2SO46H2O (1) and Cu(gly)(H2O) (bpy)Cu(gly)(SO4)(bpy)6H2O (2). Complexes were synthesized in an autoclave: copper(II) hydroxide, copper(II) sulfate pentahydrate, glycine and a heterocyclic base were mixed and heated for 30 min at 120 °C. After a few days, dark blue needles of 1 and 2 were formed. In both complexes the Cu atoms have distorted square-pyramidal geometry. In 1, Cu atom are bonded to two N atoms from the phenanthroline ligand, and N and O atoms from the glycinate ligand in a distorted square plane, with a water molecule at the apical site of the pyramid. In 2, both Cu atoms are coordinated by two N atoms from the bipyridine and by N and O atoms from the glycinate ligand, while at the apical position there is a water molecule or a sulphate anion. Both 1 and 2 have porous structures containing infinite 1D channels containing water and occupying 12.5 % and 12.9 % of unit cell volume, respectively.

copper complexes, aminoacids, heterocyclic bases, structural characterization

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