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Pregled bibliografske jedinice broj: 1000816

Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics


Raci, Pranvera Zejnullahu; Hosnjak, Lea; Poljak, Mario; Židovec Lepej, Snježana; Vince, Adriana
Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics // Ginekologia Polska, 89 (2018), 9; 485-494 doi:10.5603/GP.a2018.0083 (međunarodna recenzija, članak, znanstveni)


Naslov
Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics

Autori
Raci, Pranvera Zejnullahu ; Hosnjak, Lea ; Poljak, Mario ; Židovec Lepej, Snježana ; Vince, Adriana

Izvornik
Ginekologia Polska (0017-0011) 89 (2018), 9; 485-494

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cervical cancer ; high-risk human papillomaviruses ; Kosovo ; prevalence ; vaccination

Sažetak
Objectives: Kosovo's current health care system does not support organized nationwide cervical cancer screening and human papillomavirus (HPV) vaccination programs. To date, no reliable data are available on cervical cancer incidence and mortality in Kosovo, or on high-risk HPV (HR-HPV) prevalence and HPV type distribution. Our aim is to determinate the pre-vaccination prevalence and distribution of HR-HPVs and to assesses the associations between sociodemographic characteristics and increased risk of HPV infection in women from Kosovo. Material and methods: Detection of HR-HPV DNA in cytologically evaluated cervical smears was performed using a clinically validated Abbott RealTime High Risk HPV test, Roche Linear Array HPV Genotyping Test, HPV52 type-specific real-time PCR and an in-house GP5+/GP6+/68 PCR. Results: The crude overall prevalence of any of the HR-HPVs was estimated at 13.1% (26/199 ; 95% confidence interval (CI): 9.1-18.5%), with HPV16 being the most common type (7/26, 26.9%), followed by HPV31 and HPV51, each detected in 4/26 (15.4%) cervical specimens, HPV18, detected in 3/26 (11.5%) specimens, HPV52 and HPV66, each detected in 2/26 (7.7%) specimens, and HPV33, HPV45, HPV56, and HPV58, each detected in a single (3.9%) specimen. Women over 40 (OR = 0.36), older than 18 at sexual debut (odds ratio (OR) = 0.28), those that had delivered at least one child (OR = 0.32), and those that had a history of pregnancy termination (OR = 0.39) were at lower risk for HPV infection. Conclusion: Because more than 70% of cervical precancerous lesions could have been prevented in Kosovo using nationwide HPV-based cervical cancer screening and HPV vaccination, it is of outmost importance to implement both programs in the national health care system as soon as possible.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
143-0000000-0117 - Imunopatogeneza hepatitisa B i C (Adriana Vince, )
143-1080116-0097 - Imunološka rekonstitucija i rezistencija na lijekove u HIV-bolesnika iz Hrvatske (Snježana Židovec-Lepej, )

Ustanove
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Profili:

Avatar Url Adriana Vince (autor)

Avatar Url Snježana Židovec-Lepej (autor)

Citiraj ovu publikaciju

Raci, Pranvera Zejnullahu; Hosnjak, Lea; Poljak, Mario; Židovec Lepej, Snježana; Vince, Adriana
Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics // Ginekologia Polska, 89 (2018), 9; 485-494 doi:10.5603/GP.a2018.0083 (međunarodna recenzija, članak, znanstveni)
Raci, P., Hosnjak, L., Poljak, M., Židovec Lepej, S. & Vince, A. (2018) Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics. Ginekologia Polska, 89 (9), 485-494 doi:10.5603/GP.a2018.0083.
@article{article, year = {2018}, pages = {485-494}, DOI = {10.5603/GP.a2018.0083}, keywords = {cervical cancer, high-risk human papillomaviruses, Kosovo, prevalence, vaccination}, journal = {Ginekologia Polska}, doi = {10.5603/GP.a2018.0083}, volume = {89}, number = {9}, issn = {0017-0011}, title = {Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics}, keyword = {cervical cancer, high-risk human papillomaviruses, Kosovo, prevalence, vaccination} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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