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Pregled bibliografske jedinice broj: 1000813

Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm?


Stemberger Marić, Lorna; Židovec Lepej, Snježana; Gorenec, Lana; Grgić, Ivana; Trkulja, Vladimir; Đaković Rode, Oktavija; Roglić, Srđan; Grmoja, Tonči; Barišić, Nina; Tešović, Goran
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? // Neurological sciences, 39 (2018), 3; 471-479 doi:10.1007/s10072-017-3227-8 (međunarodna recenzija, članak, znanstveni)


Naslov
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm?

Autori
Stemberger Marić, Lorna ; Židovec Lepej, Snježana ; Gorenec, Lana ; Grgić, Ivana ; Trkulja, Vladimir ; Đaković Rode, Oktavija ; Roglić, Srđan ; Grmoja, Tonči ; Barišić, Nina ; Tešović, Goran

Izvornik
Neurological sciences (1590-1874) 39 (2018), 3; 471-479

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CXCL10 ; CXCL11 ; CXCL13 ; Acute disseminated encephalomyelitis ; Non-polio enterovirus aseptic meningitis ; Neuroborreliosis

Sažetak
We investigated potential diagnostic usefulness of serum and cerebrospinal fluid (CSF) concentrations of chemokines CXCL10, CXCL11, and CXCL13 in pediatric patients with acute disseminated encephalomyelitis (ADEM) (n = 23), non-polio enterovirus aseptic meningitis (NPEV AM) (n = 20), and neuroborreliosis (NB) (n = 21) and children with acute infectious diseases with neurological symptoms but with excluded neuroinfection/neuroinflammation (controls, n = 20). CSF levels of CXCL10 and CXCL11 were higher in patients with NPEV AM than those in other children, and CXCL10 levels showed a high discriminative potential (area under the receiver operating characteristic curve, ROC, 0.982) with high specificity and sensitivity (both 95%). CSF levels of CXCL13 were higher in NB patients than those in other children ; however, discriminative potential (area under ROC curve 0.814) and diagnostic properties were moderate (sensitivity 67%, specificity 97%). Data suggest usefulness of chemokine quantification as a diagnostic aid in children with suspected ADEM, NPEV AM, or NB.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
108-0000000-3485 - Nove metode u dijagnostici akutnih nebakterijskih upala SŽS-a u djece (Goran Tešović, )
143-1080116-0097 - Imunološka rekonstitucija i rezistencija na lijekove u HIV-bolesnika iz Hrvatske (Snježana Židovec-Lepej, )

Ustanove
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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